Search results for " Immunoregulation"

showing 3 items of 3 documents

The balance of HSPs expression during pregnancy: the role of placenta

2009

Settore BIO/16 - Anatomia Umanaplacenta placental pathologies pregnancy HSPsChaperones Immunoregulation
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Budesonide increases TLR4 and TLR2 expression in Treg lymphocytes of allergic asthmatics

2015

Abstract Background Reduced innate immunity responses as well as reduced T regulatory activities characterise bronchial asthma. Objectives In this study the effect of budesonide on the expression of TLR4 and TLR2 in T regulatory lymphocyte sub-population was assessed. Methods TLR4 and TLR2 expression in total peripheral blood mononuclear cells (PBMC), in CD4+/CD25+ and in CD4+/CD25− was evaluated, by flow cytometric analysis, in mild intermittent asthmatics (n = 14) and in controls (n = 11). The in vitro effects of budesonide in modulating: TLR4 and TLR2 expression in controls and in asthmatics; IL-10 expression and cytokine release (IL-6 and TNF-α selected by a multiplex assay) in asthmati…

AdultMalePulmonary and Respiratory MedicineBudesonidemedicine.medical_treatmentLymphocyteIn Vitro TechniquesCorticosteroids; Immunoregulation; T lymphocytes; TLR; Adult; Asthma; Budesonide; Cytokines; Female; Flow Cytometry; Glucocorticoids; Humans; In Vitro Techniques; Interleukin-10; Leukocytes Mononuclear; Male; T-Lymphocytes Regulatory; Toll-Like Receptor 2; Toll-Like Receptor 4; Young Adult; Pulmonary and Respiratory Medicine; Pharmacology (medical); Biochemistry (medical); Medicine (all)T-Lymphocytes RegulatoryPeripheral blood mononuclear cellYoung AdultGlucocorticoidTLRT lymphocytemedicineCorticosteroidHumansPharmacology (medical)IL-2 receptorBudesonideCytokineGlucocorticoidsIn Vitro Techniquebusiness.industryMedicine (all)Biochemistry (medical)ImmunoregulationFlow CytometryAsthmaToll-Like Receptor 2Interleukin-10Toll-Like Receptor 4Interleukin 10TLR2Cytokinemedicine.anatomical_structureImmunologyLeukocytes MononuclearTLR4CytokinesFemalebusinessHumanmedicine.drugPulmonary Pharmacology & Therapeutics
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Human limbal fibroblast-like stem cells induce immune-tolerance in autoreactive T lymphocytes from female patients with Hashimoto’s thyroiditis

2017

Background Due to their “natural immune privilege” and immunoregulatory properties human fibroblast-like limbal stem cells (f-LSCs) have acquired great interest as a potential tool for achieving immunotolerance. Hashimoto’s thyroiditis (HT) is the most common thyroid autoimmune disease and cause of hypothyroidism. To date, conventional hormone replacement therapy and unspecific immunosuppressive regimens cannot provide a definitive cure for HT subjects. We explored the immunosuppressant potential of human f-LSCs on circulating lymphomonocytes (PBMCs) collected from healthy donors and female HT patients. Methods We assessed the immunophenotyping of f-LSCs, both untreated and after 48 h of pr…

0301 basic medicineAdultMedicine (miscellaneous)Hashimoto DiseaseCD8-Positive T-LymphocytesInflammatory diseasesMajor histocompatibility complexBiochemistry Genetics and Molecular Biology (miscellaneous)Settore MED/13 - EndocrinologiaProinflammatory cytokineImmune tolerancelcsh:Biochemistry03 medical and health scienceschemistry.chemical_compoundHuman limbal stem cells Hashimoto’s thyroiditis Immunoregulation Tolerance induction Inflammatory diseasesImmune privilegeImmune ToleranceMedicineHumanslcsh:QD415-436Tolerance inductionCells CulturedAgedlcsh:R5-920biologybusiness.industryResearchStem CellsInterleukinImmunoregulationCarboxyfluorescein succinimidyl esterCell BiologyHashimoto’s thyroiditisFibroblastsMiddle AgedTh1 Cells030104 developmental biologychemistryImmunologybiology.proteinHuman limbal stem cellsMolecular MedicineCytokinesFemaleStem cellbusinesslcsh:Medicine (General)CD8Stem Cell Research & Therapy
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